Article
The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling.
Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2010
Hoffman Aaron E, Zheng Tongzhang, Yi Chun-Hui, Stevens Richard G, Ba Yue, Zhang Yawei, Leaderer Derek, Holford Theodore, Hansen Johnni, Zhu Yong
Abstract excerpt
As transcriptional regulators, circadian genes have the potential to influence a variety of biological pathways, including many cancer-related processes. Cryptochrome 2 (CRY2) is essential for proper circadian timing and is a key component of the circadian regulatory feedback loop. Here, we report findings from genetic, epigenetic, loss-of-function, and transcriptional profiling analyses of CRY2 in breast cancer....
Topics
- Breast Neoplasms
- Cryptochromes
- DNA Methylation
- Female
- Genetic Predisposition to Disease
- Humans
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic