Article
STING inhibitors target the cyclic dinucleotide binding pocket.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2021
Hong Ze, Mei Jiahao, Li Chenhui, Bai Guohui, Maimaiti Munire, Hu Haiyang, Yu Wenying, Sun Li, Zhang Lele, Cheng Dan, Liao Yixian, Li Senlin, You Yanping, Sun Hongbin, Huang Jing, Liu Xing, Lieberman Judy, Wang Chen
Abstract excerpt
Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING (stimulator of interferon genes) signaling, which triggers interferon and inflammatory responses that help defend against microbial infection and cancer. However, aberrant cytosolic self-DNA in Aicardi-Goutière's syndrome and constituently active gain-of-function mutations in STING in STING-associated vasculopathy with onset in...
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