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Article

A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape.

Briefings in bioinformatics - 22 Jan 2024

Sun Shengjie, Rodriguez Georgialina, Zhao Gaoshu, Sanchez Jason E, Guo Wenhan, Du Dan, Rodriguez Moncivais Omar J, Hu Dehua, Liu Jing, Kirken Robert Arthur, Li Lin

Abstract excerpt

The family of Janus Kinases (JAKs) associated with the JAK-signal transducers and activators of transcription signaling pathway plays a vital role in the regulation of various cellular processes. The conformational change of JAKs is the fundamental steps for activation, affecting multiple intracellular signaling pathways. However, the transitional process from inactive to active kinase is still a mystery. This...

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Identifiers

PMID: 38446738
DOI: 10.1093/bib/bbae079
PMCID: PMC10939344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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