Article

Dysfunctional vascular smooth muscle cells mediate early and late-stage neuroinflammation and Tau hyperphosphorylation

2021-04-14

Abstract excerpt

<h4>SUMMARY</h4> Despite the emerging evidence implying early vascular contributions to neurogenerative syndromes, the role of vascular smooth muscle cells (VSMCs) in the pathogenesis of Alzheimer’s disease is still not well understood. Herein, we show that VSMCs in brains of AD patients and the animal model of the disease, are deficient in multiple VSMC-contractile markers which correlated with Tau accumulation...

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Literature Corpus work: a6d01b90-1bc1-5337-b3df-1584faa24a9c
DOI: 10.1101/2021.04.13.439741

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