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Article

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007

Chow Nienwen, Bell Robert D, Deane Rashid, Streb Jeffrey W, Chen Jiyuan, Brooks Andrew, Van Nostrand William, Miano Joseph M, Zlokovic Berislav V

Abstract excerpt

Cerebral angiopathy contributes to cognitive decline and dementia in Alzheimer's disease (AD) through cerebral blood flow (CBF) reductions and dysregulation. We report vascular smooth muscle cells (VSMC) in small pial and intracerebral arteries, which are critical for CBF regulation, express in AD high levels of serum response factor (SRF) and myocardin (MYOCD), two interacting transcription factors that...

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Source

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Identifiers

PMID: 17215356
DOI: 10.1073/pnas.0608251104
PMCID: PMC1783398

Genes

MYOCD
SRF
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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