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Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing

31 Mar 2022

Abstract excerpt

Early vascular ageing (EVA) is a pathological phenomenon whereby the vascular system ages more quickly than chronological age. This underpins many cardiovascular diseases including the complications of type 2 diabetes, aneurysm formation and hypertension. Smooth muscle cells (SMC) are the principal cell type in the vascular wall and maintain vascular tone. EVA-related phenotypic switching of these cells...

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PMID: 35367337
DOI: 10.1016/j.bbadis.2022.166403

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