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Article

SM22α Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.

International journal of molecular sciences - 12 Apr 2023

Xu Xin, Liu Xiao-Qin, Liu Xin-Long, Wang Xu, Zhang Wen-Di, Huang Xiao-Fu, Jia Fang-Yue, Kong Peng, Han Mei

Abstract excerpt

Considerable evidence now indicates that cognitive impairment is primarily a vascular disorder. The depletion of smooth muscle 22 alpha (SM22α) contributes to vascular smooth muscle cells (VSMCs) switching from contractile to synthetic and proinflammatory phenotypes in the context of inflammation. However, the role of VSMCs in the pathogenesis of cognitive impairment remains undetermined. Herein, we showed a...

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Identifiers

PMID: 37108281
DOI: 10.3390/ijms24087117
PMCID: PMC10138350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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