Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal Thickness.

doi:10.1167/iovs.67.11.38

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Article

Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal Thickness.

Investigative ophthalmology & visual science - 1 Sept 2026

Borchert Grace A, Ferreira Lino A F, Raji Shabnam, Yu Jing, Segovia Matias, MacLaren Robert E, Downes Susan M, Cehajic-Kapetanovic Jasmina, Xue Kanmin, De Silva Samantha R

Abstract excerpt

Purpose: Age-related macular degeneration (AMD) is a leading cause of visual impairment in individuals >50 years. The APOE2 allele has been associated with increased AMD risk compared to the common APOE3 allele. However, the retinal phenotype of APOE2/2 individuals has not been characterized. This study aimed to compare the macular structure and function of APOE2/2 versus APOE3/3 homozygous individuals. Methods:...

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Topics

Humans
Female
Apolipoprotein E2
Male
Genotype
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Choroid

Tomography, Optical Coherence

Prospective Studies

Macular Degeneration

Visual Acuity

Aged

Apolipoprotein E3

Source

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Identifiers

PMID: 42757924
DOI: 10.1167/iovs.67.11.38
PMCID: PMC13614145

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