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Article

Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology.

International journal of molecular sciences - 14 Feb 2020

Koren-Iton Amit, Salomon-Zimri Shiran, Smolar Alex, Shavit-Stein Efrat, Dori Amir, Chapman Joab, Michaelson Daniel M

Abstract excerpt

Apolipoprotein E (APOE) ε4 gene allele and type 2 diabetes mellitus (T2DM) are prime risk factors for Alzheimer's disease (AD). Despite evidence linking T2DM and apoE4, the mechanism underlying their interaction is yet to be determined. In the present study, we employed a model of APOE-targeted replacement mice and high-fat diet (HFD)-induced insulin resistance to investigate diabetic mechanisms associated with...

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Identifiers

PMID: 32075060
DOI: 10.3390/ijms21041289
PMCID: PMC7072920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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