Article

The neuronal fate determinants SOX4/11 control mitotic fidelity of adult hippocampal precursor cells

2025-10-14

Abstract excerpt

In adult hippocampal neurogenesis, fast dividing intermediate progenitor cells (IPCs) ensure the production of a larger number of neurons from a limited pool of slow dividing radial-glia-like neural stem cells. Here, we demonstrate that the neuronal fate determining and lineage-specific transcription factors SOX4 and SOX11 are essential to faithfully execute mitosis in IPCs. In vivo, combined deletion of SOX4 and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a67f4e92-ec09-5905-b620-f521bd50f510
DOI: 10.1101/2025.10.13.682016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The neuronal fate determinants SOX4/11 control mitotic fidelity of adult hippocampal precursor cellsDOI 10.1101/2025.10.13.682016Read

The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesisSemantic proximity Read

Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental DisordersSemantic proximity Read

Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.Semantic proximity Read

Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repressionSemantic proximity Read

The microcephaly gene <i>ASPM</i> is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientationSemantic proximity Read

Slit/Robo signaling modulates the proliferation of central nervous system progenitors.Semantic proximity Read

Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex.Semantic proximity Read

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.Semantic proximity Read

Loss of symmetric cell division of apical neural progenitors drives<i>DENND5A</i>-related developmental and epileptic encephalopathySemantic proximity Read

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular ZoneSemantic proximity Read

Id4 is required for the correct timing of neural differentiation.Semantic proximity Read

SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.Semantic proximity Read