Article
Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex.
Neuron - 20 Oct 2011
Postiglione Maria Pia, Jüschke Christoph, Xie Yunli, Haas Gerald A, Charalambous Christoforos, Knoblich Juergen A
Abstract excerpt
Neurons in the mammalian neocortex arise from asymmetric divisions of progenitors residing in the ventricular zone. While in most progenitor divisions, the mitotic spindle is parallel to the ventricular surface, some progenitors reorient the spindle and divide in oblique orientations. Here, we use conditional deletion and overexpression of mouse Inscuteable (mInsc) to analyze the relevance of spindle...
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