Article

The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis

2023-01-14

Abstract excerpt

Mutations in components of the exon junction complex (EJC) are associated with neurodevelopment and disease. In particular, reduced levels of the RNA helicase EIF4A3 cause Richieri-Costa-Pereira Syndrome (RCPS) and CNVs are linked to intellectual disability. Consistent with this, Eif4a3 haploinsufficient mice are microcephalic. Altogether, this implicates EIF4A3 in cortical development; however, the underlying m...

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Literature Corpus work: 849e48db-f16a-5ab6-8c90-ec7791185c43
DOI: 10.1101/2023.01.13.524010

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