Article

Tuberculosis treatment failure associated with evolution of antibiotic resilience

2022-03-29

Abstract excerpt

Antibiotics are a cornerstone of medicine, placing bacterial pathogens under intense pressure to evolve new survival mechanisms. Analysis of 51,229 Mycobacterium tuberculosis (Mtb) clinical isolates identified an essential transcriptional regulator, Rv1830 ( here named resR) as a frequent target of positive (adaptive) selection. resR mutants do not demonstrate canonical drug resistance or drug tolerance but in...

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Literature Corpus work: a662ebaf-36a4-5d3b-afc9-db60dc438636
DOI: 10.1101/2022.03.29.486233

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