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Article

Tuberculosis treatment failure associated with evolution of antibiotic resilience

8 Dec 2022

Abstract excerpt

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis ( Mtb ) clinical isolates has identified an essential transcriptional regulator, Rv1830 , herein called resR for resilience regulator, as a frequent target of positive (adaptive) selection. resR mutants do not show canonical drug...

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PMID: 36480634
DOI: 10.1126/science.abq2787

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