Article
Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out.
Trends in microbiology - 1 Aug 2016
Eldholm Vegard, Balloux François
Abstract excerpt
Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium tuberculosis (Mtb). It is an obligate human pathogen with limited genetic diversity and a low mutation rate which lacks any evidence for HGT. Such features should, in principle, reduce its ability to rapidly evolve AMR. We identify key features in...
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