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Article

A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus.

Journal of applied microbiology - 4 Nov 2024

De Boeck Nathan, Villellas Cristina, Crespo-Yuste Estefanía, Gonzalo-Asensio Jesús, Buckley Peter T, Thys Kim, Vuong Cuong, Lounis Nacer, Verstraeten Natalie, Michiels Jan

Abstract excerpt

AIMS: We aimed to investigate the molecular mechanisms underlying the survival of Mycobacterium abscessus when faced with antibiotic combination therapy. By conducting evolution experiments and whole-genome sequencing (WGS), we sought to identify genetic variants associated with stress response mechanisms, with a particular focus on drug survival and resistance. METHODS AND RESULTS: We conducted evolution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39537195
DOI: 10.1093/jambio/lxae286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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