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Article

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.

International journal of molecular sciences - 1 Aug 2026

López-Roa Paula, Esteban Jaime, Muñoz-Egea María-Carmen

Abstract excerpt

Antimicrobial resistance in mycobacteria arises from a complex interplay of intrinsic and acquired mechanisms that collectively limit the efficacy of current therapeutic options. Intrinsic resistance is largely driven by the low permeability of the mycobacterial cell envelope, the activity of efflux pumps, and the presence of drug-modifying enzymes, which together restrict intracellular drug accumulation and...

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PMID: 42589549
DOI: 10.3390/ijms27156893
PMCID: PMC13467208

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NTM

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