Article

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

2019-06-11

Abstract excerpt

<h4>Background</h4> The oncogene LSF (encoded by TFCP2 ) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colorectal cancer. The limited treatment outcomes for these diseases underscore the need for molecularly targeting novel mechanisms. LSF small molecule inhibitors, Fact...

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Literature Corpus work: a658fa8f-0b28-515f-b54e-d9b9d47d3784
DOI: 10.1101/665570

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