Article

A small molecule that promotes cellular senescence prevents fibrogenesis and tumorigenesis <i>in vitro</i>

2021-06-01

Abstract excerpt

<h4>Background</h4> Uncontrolled proliferative diseases such as fibrosis or cancer can be fatal. We previously found that a compound containing a chromone scaffold, ONG41008, had potent anti-fibrotic effects in diseased human lung myofibroblasts but not normal human lung fibroblasts. <h4>Methods</h4> We investigated the effects of ONG41008 on tumor cells, and compared these effects with those in pathogenic myofi...

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Identifiers and source

Literature Corpus work: e017ecc2-91f6-54fa-82b1-bfae743b07b9
DOI: 10.1101/2021.06.01.446522

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