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Article

Acute loss of transcription factor E2F1 induces mitochondrial biogenesis in Hela cells

13 Sept 2006

Abstract excerpt

Here, we sought to clarify the comprehensive cellular response to transcription factor E2F1 expression using short interfering RNA (siRNA)-mediated gene silencing to examine the roles of E2F1. For this purpose, we analyzed global gene expression changes in E2F1 knockdown HeLa cells, where no changes in cell growth or apoptosis were observed. Among the identified genes, the mRNA levels of mitochondria-encoded...

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PMID: 16972274
DOI: 10.1002/jcp.20802

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