Article

Systematic analysis uncovers SYK dependency in NF1 <sup>LoF</sup> melanoma cells

2022-03-07

Abstract excerpt

The loss of function (LoF) of NF1 is the third most frequent mutation that drives hyperactivated RAS and tumor growth in >10% of melanomas. NF1 LoF melanoma cells, however, do not show consistent sensitivity to individual MEK, ERK, or PI3K/mTOR inhibitors. Here, we perform a targeted kinase inhibitor screen and identify a tool compound, named MTX-216, to be highly effective in blocking NF1 LoF melanoma cells. Si...

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Literature Corpus work: 152a3707-0253-50e0-acd6-9c78f44c975c
DOI: 10.1101/2022.03.06.483170

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