Article
SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.
Cell reports - 22 Sept 2020
Klotz-Noack Kathleen, Klinger Bertram, Rivera Maria, Bublitz Natalie, Uhlitz Florian, Riemer Pamela, Lüthen Mareen, Sell Thomas, Kasack Katharina, Gastl Bastian, Ispasanie Sylvia S S, Simon Tincy, Janssen Nicole, Schwab Matthias, Zuber Johannes, Horst David, Blüthgen Nils, Schäfer Reinhold, Morkel Markus, Sers Christine
Abstract excerpt
Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly relapse with reactivation of the targeted pathways. We identify the nuclear protein SFPQ to be synthetically lethal with BRAFV600E in a loss-of-function shRNA screen. SFPQ...
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