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Article

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.

Oncotarget - 22 Sept 2015

Rajasekaran Devaraja, Siddiq Ayesha, Willoughby Jennifer L S, Biagi Jessica M, Christadore Lisa M, Yunes Sarah A, Gredler Rachel, Jariwala Nidhi, Robertson Chadia L, Akiel Maaged A, Shen Xue-Ning, Subler Mark A, Windle Jolene J, Schaus Scott E, Fisher Paul B, Hansen Ulla, Sarkar Devanand

Abstract excerpt

Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in promoting HCC. A small molecule inhibitor of LSF, Factor Quinolinone Inhibitor 1 (FQI1), significantly inhibited human HCC...

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Identifiers

PMID: 26313006
DOI: 10.18632/oncotarget.4656
PMCID: PMC4694900

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26313006-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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