Article
Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Oncotarget - 22 Sept 2015
Rajasekaran Devaraja, Siddiq Ayesha, Willoughby Jennifer L S, Biagi Jessica M, Christadore Lisa M, Yunes Sarah A, Gredler Rachel, Jariwala Nidhi, Robertson Chadia L, Akiel Maaged A, Shen Xue-Ning, Subler Mark A, Windle Jolene J, Schaus Scott E, Fisher Paul B, Hansen Ulla, Sarkar Devanand
Abstract excerpt
Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in promoting HCC. A small molecule inhibitor of LSF, Factor Quinolinone Inhibitor 1 (FQI1), significantly inhibited human HCC xenografts in nude mice without harming normal cells. Here we evaluated the efficacy of FQI1 and another inhibitor,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.