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Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells

26 May 2011

Abstract excerpt

Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5'->3' human DNA helicase that exhibits broad substrate specificity. In vitro studies have implicated PIF1 in maintaining telomeres and processing stalled DNA replication forks, but disruption of the murine Pif1 gene did not yield any apparent phenotype. In this study, we...

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PMID: 21616935
DOI: 10.1158/0008-5472.can-10-4404

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