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Article

Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Olive Claudia, Ibanez Laura, Farias Fabiana H Geraldo, Wang Fengxian, Budde John P, Norton Joanne B, Gentsch Jen, Morris John C, Li Zeran, Dube Umber, Del-Aguila Jorge, Bergmann Kristy, Bradley Joseph, Benitez Bruno A, Harari Oscar, Fagan Anne, Ances Beau, Cruchaga Carlos, Fernandez Maria Victoria

Abstract excerpt

BACKGROUND: Rare variants in PLCG2 (p.P522R), ABI3 (p.S209F), and TREM2 (p.R47H, p.R62H) have been associated with late onset Alzheimer's disease (LOAD) risk in Caucasians. After the initial report, several studies have found positive results in cohorts of different ethnic background and with different phenotype. OBJECTIVE: In this study, we aim to evaluate the association of rare coding variants in PLCG2, ABI3,...

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Identifiers

PMID: 32894242
DOI: 10.3233/JAD-200019
PMCID: PMC7927150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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