Article

BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease-linked proteins via proteasome, autophagy, and retromer complex interactions

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone assisted selective autophagy, and in the brain, most highly expressed in astrocytes. However, its role in astrocytes remains poorly defined. Given the genetic and pathological links of BAG3 to proteostasis and neurodegenerative diseases, we investigated how BAG3 contributes to astrocyte function and Alzheimer’s...

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Literature Corpus work: 5b3cbade-63c8-5eae-98c5-f76f5632f044
DOI: 10.1101/2025.09.20.677505

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