Article

Improving the fidelity of uridine analog incorporation during <i>in vitro</i> transcription

2022-04-13

Abstract excerpt

In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality and are currently being evaluated for a wide range of clinical indications. To overcome the inherent immunogenicity of the synthetic mRNAs, as well as to increase the therapeutic efficacy of the molecules, RNA sequence optimization is routinely performed and modified uridine analogs—such as pseudouridine (Ψ) and N 1 -meth...

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Literature Corpus work: a64b68f5-870c-5af2-9707-f119a370245f
DOI: 10.1101/2022.04.12.488100

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