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Article

N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

1 Aug 2022

Abstract excerpt

Synthetic mRNA technology is a promising avenue for treating and preventing disease. Key to the technology is the incorporation of modified nucleotides such as N1-methylpseudouridine (m1Ψ) to decrease immunogenicity of the RNA. However, relatively few studies have addressed the effects of modified nucleotides on the decoding process. Here, we investigate the effect of m1Ψ and the related modification...

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Share to RNA and protein synthesis mechanisms
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PMID: 35988540
DOI: 10.1016/j.celrep.2022.111300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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