Article

RluA is the major mRNA pseudouridine synthase in <i>Escherichia coli</i>

2023-12-12

Abstract excerpt

Pseudouridine (Ψ) is an ubiquitous RNA modification, present in the tRNAs and rRNAs of species across all domains of life. Conserved pseudouridine synthases modify the mRNAs of diverse eukaryotes, but the modification has yet to be identified in bacterial mRNAs. Here, we report the discovery of pseudouridines in mRNA from E. coli . By testing the mRNA modification capacity of all 11 known pseudouridine synthases,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2f950df-7e4e-5509-b3b2-1c47f711ba17
DOI: 10.1101/2023.12.08.570740

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RluA is the major mRNA pseudouridine synthase in <i>Escherichia coli</i>DOI 10.1101/2023.12.08.570740Read

Quantitative mapping of pseudouridines in bacteria RNASemantic proximity Read

Recent developments, opportunities, and challenges in the study of mRNA pseudouridylationSemantic proximity Read

Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in TranslationSemantic proximity Read

mRNA structure determines modification by pseudouridine synthase 1.Semantic proximity Read

Exploring pseudouridylation: dysregulation in disease and therapeutic potentialSemantic proximity Read

Pseudouridine-Free Escherichia coli Ribosomes.Semantic proximity Read

Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modificationsSemantic proximity Read

Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect splicingSemantic proximity Read

RNA-guided isomerization of uridine to pseudouridine--pseudouridylation.Semantic proximity Read

Mechanistic insight into the pseudouridylation of RNASemantic proximity Read

Discovery of Pyrobaculum small RNA families with atypical pseudouridine guide RNA features.Semantic proximity Read

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAProSemantic proximity Read