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N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

6 Dec 2023

Abstract excerpt

Abstract In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect 1,2 . Modified...

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PMID: 38057663
DOI: 10.1038/s41586-023-06800-3

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