Article

Structure-Based Computational Analysis of Interactions between Insulin Receptor and Insulin Inhibitory Receptor

2024-09-11

Abstract excerpt

<h4>ABSTRACT</h4> The recently discovered insulin inhibitory receptor (inceptor) plays a crucial role in insulin resistance and diabetes by reducing the insulin receptor count on cell membranes, resulting in higher blood glucose levels and decreased insulin sensitivity. Therefore, understanding the mechanism of how the inceptor insulin receptor complex interacts is exceedingly important. This study uses computati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a649537d-6e3f-57bb-8c8a-f32c700b5d8b
DOI: 10.1101/2024.09.06.611694

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure-Based Computational Analysis of Interactions between Insulin Receptor and Insulin Inhibitory ReceptorDOI 10.1101/2024.09.06.611694Read

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed AgonistsSemantic proximity Read

Structural Dynamics of Insulin Receptor and Transmembrane Signaling.Semantic proximity Read

Insulin receptor activation with transmembrane domain ligands.Semantic proximity Read

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin ReceptorSemantic proximity Read

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistanceSemantic proximity Read

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin IcodecSemantic proximity Read

Identification of INSR protein structural differences in Diabetes Mellitus type 2 subjects from protein sequencesSemantic proximity Read

In Silico Design of a Multimodal Trimeric Peptide Candidate Predicted to Simultaneously Target Glycemic Control, Autoimmunity, and Pancreatic β-Cell Regeneration in Type 1 DiabetesSemantic proximity Read

Diabetes mellitus caused by mutations in human insulin: analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics.Semantic proximity Read

A λ-dynamics investigation of insulin <i>Wakayama</i> and other A3 variant binding affinities to the insulin receptorSemantic proximity Read

Recent Applications of In Silico Approaches for Studying Receptor Mutations Associated with Human Pathologies.Semantic proximity Read

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2.Semantic proximity Read