Article

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance

2026-05-07

Abstract excerpt

Computational protein engineering provides a powerful approach to address longstanding clinical challenges. Severe insulin resistance syndromes caused by mutations in the insulin receptor (IR) are life-threatening disorders for which effective long-term therapies remain lacking. Here, we define the in vivo activity and therapeutic potential of RF-409, a de novo–designed IR agonist that activates the receptor throu...

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Literature Corpus work: 56f67368-e719-577e-82e8-0d81fc6f892f
DOI: 10.64898/2026.05.04.722722

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