Article

In Silico Design of a Multimodal Trimeric Peptide Candidate Predicted to Simultaneously Target Glycemic Control, Autoimmunity, and Pancreatic β-Cell Regeneration in Type 1 Diabetes

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction:</bold> Type 1 diabetes mellitus (T1DM) currently affects 9.5 million individuals worldwide, with incidence rising through 2040. Clinical management remains anchored to exogenous insulin replacement, which neither arrests autoreactive CD8⁺ T-cell–mediated insulitis, nor blocks IL-1β–driven β-cell apoptosis, nor restores PDX-1/NGN3-dependent endocrine identity. No a...

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Literature Corpus work: 5812e3ee-833b-5bb8-8e81-8955f4f9a5f9
DOI: 10.21203/rs.3.rs-8951973/v1

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