Article

A λ-dynamics investigation of insulin <i>Wakayama</i> and other A3 variant binding affinities to the insulin receptor

2024-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Insulin Wakayama is a clinical insulin variant where a conserved valine at the third residue on insulin’s A chain (Val A3 ) is replaced with a leucine (Leu A3 ), impairing insulin receptor (IR) binding by 140-500 fold. This severe impact on binding from such a subtle modification has posed an intriguing problem for decades. Although experimental investigations of natural and unnatural A3 muta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3197b3c7-52f2-5677-8a60-733793801c1a
DOI: 10.1101/2024.03.15.585233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A λ-dynamics investigation of insulin <i>Wakayama</i> and other A3 variant binding affinities to the insulin receptorDOI 10.1101/2024.03.15.585233Read

A λ-Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor.Semantic proximity Read

Diabetes mellitus caused by mutations in human insulin: analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics.Semantic proximity Read

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin ReceptorSemantic proximity Read

All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.Semantic proximity Read

Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding.Semantic proximity Read

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.Semantic proximity Read

Structure-Based Computational Analysis of Interactions between Insulin Receptor and Insulin Inhibitory ReceptorSemantic proximity Read

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed AgonistsSemantic proximity Read

Structural insights into conformational stability of both wild-type and mutant Insulin Receptor GeneSemantic proximity Read

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Semantic proximity Read

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin IcodecSemantic proximity Read

How ligand binds to the type 1 insulin-like growth factor receptor.Semantic proximity Read