Article

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin Icodec

2024-04-29

Abstract excerpt

Insulin therapy is a cornerstone in the management of diabetes, yet the pursuit of optimizing its pharmacokinetic profile remains a focal point in diabetes research. For instance, insulin icodec of Novo Nordisk is a novel long-acting insulin analogue that exhibits an extended duration of action, providing a promising once-weekly treatment option for diabetic patients. However, designing insulin analogues with lowe...

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Literature Corpus work: ddde9cb0-6c98-5387-8cd9-506c3070dddf
DOI: 10.20944/preprints202404.1922.v1

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