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Article

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2.

Vitamins and hormones - 1 Jan 2023

Jiráček Jiří, Selicharová Irena, Žáková Lenka

Abstract excerpt

Elucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the...

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Identifiers

PMID: 37717985
DOI: 10.1016/bs.vh.2023.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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