Insulin receptor activation with transmembrane domain ligands.

Abstract excerpt

Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and activate cellular receptors. Although these extended surfaces provide high affinity and specificity to the interactions, they also present great challenges to the design of small molecules that might either mimic or antagonize the process. We show that the insulin receptor (IR) and downstream signals can be activated by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insulin Resistance
• Share to CHO Cells
• Share to Cricetinae