Article

Genetic silencing of K <sub>Ca</sub> 3.1 inhibits atherosclerosis in ApoE null mice

2024-12-16

Abstract excerpt

Increased expression of K Ca 3.1 has been found in vascular smooth muscle (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Proliferating SMC cells increase the expression of K Ca 3.1, such that it becomes a dominant K + channel and contributes to SMC cell migration. The efficacy of pharmacological inhibition of K Ca 3.1 in limiting atherosclerosis progression has been demonstrat...

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Literature Corpus work: a6331da2-b90f-5301-9605-41822a5958b1
DOI: 10.1101/2024.12.11.628017

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