Article

K <sub>Ca</sub> 3.1 Drives Pro-Fibrotic Activation and Represents a Novel Therapeutic Target in Aortic Stenosis

2026-05-04

Abstract excerpt

<h4>Introduction</h4> Aortic stenosis (AS) is characterised by progressive aortic valve (AV) leaflet fibrosis and calcification, yet no medical therapies exist to slow disease progression. AV interstitial cells (VICs) that differentiate into myofibroblasts are central drivers of fibrosis. The Ca 2+ -activated K + channel K Ca 3.1 promotes pro-fibrotic signalling in several fibrotic diseases, however its role i...

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Literature Corpus work: a6e3d375-750d-5c75-8535-d7393a63c98a
DOI: 10.64898/2026.04.30.720379

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