Genetic silencing of K Ca 3.1 inhibits atherosclerosis in ApoE null mice

Abstract excerpt

Increased expression of KCa3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of KCa3.1 in limiting atherosclerosis has been demonstrated in mice and pigs, however direct, loss-of-function, i.e. gene silencing, studies are absent. Therefore, we generated KCa3.1−/−Apoe−/− (DKO) mice and assessed lesion...

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