Article

A spatial map of human macrophage niches reveals context-dependent macrophage functions in colon and breast cancer.

2023-01-10

Abstract excerpt

<title>Abstract</title> Tumor-associated macrophages (TAMs) display heterogeneous phenotypes. Yet the exact tissue cues that shape macrophage functional diversity are incompletely understood. Here we discriminate, spatially resolve and reveal the function of five distinct macrophage niches within malignant and benign breast and colon tissue. We found that SPP1 TAMs reside in hypoxic and necrotic tumor regions,...

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Literature Corpus work: a61a58c9-f010-5e31-96f9-163bca495294
DOI: 10.21203/rs.3.rs-2393443/v1

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