Article

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

2023-10-27

Abstract excerpt

<h4>Summary</h4> Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt diverse phenotypic alterations, giving rise to heterogeneous immune activation states and induction of cell cycle. While the transcriptional profiles...

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Literature Corpus work: 81282daf-307f-5ba2-934f-c5bd4d48f067
DOI: 10.1101/2023.10.24.563749

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