Back to search

Article

SPP1+ macrophages: A malignant macrophage subset in the colorectal cancer microenvironment revealed by single-cell sequencing

2022-09-07

Abstract excerpt

<title>Abstract</title><p>Accumulating single-cell studies suggest that SPP1 + macrophages are key players in the tumor microenvironment. However, a systematic investigation of SPP1 + macrophages in colorectal cancer (CRC) has not been conducted. A total of eight single-cell RNA-seq datasets and 16 bulk RNA-seq datasets were included in this study. On the basis of existing research, we propose the SPP1 + macrophag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8f0b6e5c-1c16-5603-8a63-792c9bb3843f
DOI
10.21203/rs.3.rs-1984416/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SPP1+ macrophages: A malignant macrophage subset in the colorectal cancer microenvironment revealed by single-cell sequencingDOI 10.21203/rs.3.rs-1984416/v1
Systematic analysis and experimental validation of the prognostic and immunological effects of SPP1 tumor-associated macrophage features in colorectal cancerSemantic proximity
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancerSemantic proximity
Evaluating the role of IDO1 macrophages in immunotherapy using scRNA-seq and bulk-seq in colorectal cancerSemantic proximity
Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated <i>SPP1</i> <sup>+</sup> macrophages and fibroblastsSemantic proximity
Single-cell RNA-seq integration unveils liver vulnerability to tumor metastases: insights from myeloid cell characterization in pancreatic cancer liver metastaticSemantic proximity
Integration of single-cell sequencing and experimental validation identified P2RY13/NF-κB as an immunological factor of patients with colorectal cancerSemantic proximity
Tumor-associated macrophage-specific SERPING1 contributes to M1-phenotype transition and suppress colorectal cancer tumorigenesis via NF-κB pathway.Semantic proximity
Integrated analysis of single-cell and bulk RNA-seq unravels the role of macrophage markers ceRNA networks in colorectal cancer’s immune microenvironment and chemotherapy sensitivitySemantic proximity
Identification of SPP1+ macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomicsSemantic proximity
Identification of macrophage-related molecular subgroups and risk signature in colorectal cancer based on a bioinformatics analysisSemantic proximity
Multi-Transcriptomic Analysis Reveals the Heterogeneity and Tumor-Promoting Role of SPP1/CD44-Mediated Intratumoral Crosstalk in Gastric CancerSemantic proximity
Single-cell RNA sequencing and large-scale bulk combination with machine learning reveal gastric cancer-related macrophage heterogeneitySemantic proximity
Select a neighboring publication to make it the new centre.