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Article

Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity.

Communications biology - 28 Mar 2023

Avalos Diana, Rey Guillaume, Ribeiro Diogo M, Ramisch Anna, Dermitzakis Emmanouil T, Delaneau Olivier

Abstract excerpt

Studying the interplay between genetic variation, epigenetic changes, and regulation of gene expression is crucial to understand the modification of cellular states in various conditions, including immune diseases. In this study, we characterize the cell-specificity in three key cells of the human immune system by building cis maps of regulatory regions with coordinated activity (CRDs) from ChIP-seq peaks and...

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Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 36977773
DOI: 10.1038/s42003-023-04688-3
PMCID: PMC10050075

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