Protein-protein interactions in the membrane: sequence, structural, and biological motifs.

doi:10.1016/j.str.2008.05.007

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Article

Protein-protein interactions in the membrane: sequence, structural, and biological motifs.

Structure (London, England : 1993) - 1 Jul 2008

Moore David T, Berger Bryan W, DeGrado William F

Abstract excerpt

Single-span transmembrane (TM) helices have structural and functional roles well beyond serving as mere anchors to tether water-soluble domains in the vicinity of the membrane. They frequently direct the assembly of protein complexes and mediate signal transduction in ways analogous to small modular domains in water-soluble proteins. This review highlights different sequence and structural motifs that direct TM...

Topics

Amino Acid Motifs
Amino Acid Sequence
Genetic Diseases, Inborn
Humans
Membrane Proteins
Models, Molecular
Molecular Sequence Data
Mutation
Protein Interaction Domains and Motifs
Receptors, Immunologic

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Identifiers

PMID: 18611372
DOI: 10.1016/j.str.2008.05.007
PMCID: PMC3771515

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