Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Scientific reports - 12 Mar 2015

Botelho Hugo M, Uliyakina Inna, Awatade Nikhil T, Proença Maria C, Tischer Christian, Sirianant Lalida, Kunzelmann Karl, Pepperkok Rainer, Amaral Margarida D

Abstract excerpt

Plasma membrane proteins are essential molecules in the cell which mediate interactions with the exterior milieu, thus representing key drug targets for present pharma. Not surprisingly, protein traffic disorders include a large range of diseases sharing the common mechanism of failure in the respective protein to reach the plasma membrane. However, specific therapies for these diseases are remarkably lacking....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Share to Genes, Reporter

Share to High-Throughput Screening Assays

Share to Patch-Clamp Techniques

Share to RNA, Small Interfering

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 25762484
DOI: 10.1038/srep09038
PMCID: PMC4356983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.PMID 25762484Read ↗

Traffic Jam: A Compendium of Human Diseases that Affect Intracellular Transport ProcessesSemantic proximity Read ↗

Traffic jams II: an update of diseases of intracellular transport.Semantic proximity Read ↗

Functional genomics assays to study CFTR traffic and ENaC function.Semantic proximity Read ↗

Cystic fibrosis: a multiple exocrinopathy caused by dysfunctions in a multifunctional transport protein.Semantic proximity Read ↗

A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies.Semantic proximity Read ↗

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosisSemantic proximity Read ↗

Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern.Semantic proximity Read ↗

A multiplexed approach for genetic screening of human cells by electron microscopy uncovers a critical effector of mitochondrial cristae shapeSemantic proximity Read ↗

The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.Semantic proximity Read ↗

Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.Semantic proximity Read ↗

Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects.Semantic proximity Read ↗

Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.