Profiling the organ membrane proteome dysregulation in the context of liver disease

Abstract excerpt

Alcohol consumption and high-fat diets often coincide in Western society, exerting negative synergistic effects on the liver. While many studies have demonstrated the impact of ALD and NAFLD on organ protein expression, none have offered a comprehensive view of the dysregulation at the level of the membrane proteome. In this study, we utilize peptidisc and solvent precipitation (SP4) methods to isolate and compare...

Topics

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• Acetylation
• Endoplasmic Reticulum Stress and Disease
• Fatty Liver
• Glycosylation
• High-Throughput Screening Assays
• Immunoassay
• Lipid metabolism and biosynthesis
• Liver Disease Diagnosis and Treatment

Identifiers and source

Literature Corpus work

34e48ab6-34ff-5d4c-b9ba-855d357d1b8c

DOI

10.1101/2024.04.05.588300