Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.

BMC cardiovascular disorders - 13 Jun 2026

Najd-Hassan-Bonab Leila, Moazzam-Jazi Maryam, Khalili Davood, Mahdavi Maryam, Khalili Mitra, Daneshpour Maryam S

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) utilize genetic variants to evaluate susceptibility to diseases. While the performance of PRS has been extensively studied in European populations, its accuracy and validation in the Middle East, particularly in Iran, remain underexplored. We aimed to assess whether PRSs improve coronary artery disease (CAD) prediction beyond clinical risk factors using sex-stratified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease
Share to Decision Support Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Incidence

Share to Longitudinal Studies

Share to Multifactorial Inheritance

Share to Predictive Value of Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 42288717
DOI: 10.1186/s12872-026-06049-4
PMCID: PMC13348432

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.PMID 42288717Read ↗

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.Semantic proximity Read ↗

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in MenSemantic proximity Read ↗

Sex-specific survival bias and interaction modeling in coronary artery disease risk predictionSemantic proximity Read ↗

Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores: evidence from the China Kadoorie Biobank.Semantic proximity Read ↗

Evaluating cardiovascular disease risk stratification using multiple-polygenic risk scores and pooled cohort equations: insights from a 17-year longitudinal Korean cohort studySemantic proximity Read ↗

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read ↗

Sex-Specific Polygenic Risk Scores for Cardiovascular Disease: A Multi-Ethnic Analysis Using the 1000 Genomes ProjectSemantic proximity Read ↗

Combining European and U.S. risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus StudySemantic proximity Read ↗

Meta-Prediction of Coronary Artery Disease RiskSemantic proximity Read ↗

Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk PredictionSemantic proximity Read ↗

Polygenic risk scores in coronary artery disease.Semantic proximity Read ↗

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.