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Article

Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting

2025-01-14

Abstract excerpt

<h4>Background</h4> For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined with cisplatin nearly universally results in death. Although hyperactivation of the Nrf2 pathway can drive radiation and cisplatin resistance along with suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary to synergistic leth...

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Literature Corpus work
a5c2c13d-89e7-50d1-8586-9f42684e68ac
DOI
10.1101/2025.01.10.632413
Open publication

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Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targetingDOI 10.1101/2025.01.10.632413
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