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Article

Cisplatin-induced genetic alterations in KEAP1 promote therapeutic resistance in head and neck squamous cell carcinoma.

Redox biology - 1 Oct 2025

Nakayama Yuki, Taguchi Keiko, Wakamori Shun, Uruno Akira, Otsuki Akihito, Ohkoshi Akira, Shirota Hidekazu, Iwasaki Tomoyuki, Katori Yukio, Yamamoto Masayuki

Abstract excerpt

Cisplatin (CDDP) resistance remains a major challenge in the treatment of recurrent head and neck squamous cell carcinoma (HNSCC). The KEAP1-NRF2 system, a central regulator of cellular redox homeostasis, is frequently altered in cancer, but its contribution to acquired CDDP resistance in HNSCC remains to be clarified. To address this, we investigated NRF2 activation in CDDP resistance using seven parental (P)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kelch-Like ECH-Associated Protein 1

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Source

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Identifiers

PMID: 40834643
DOI: 10.1016/j.redox.2025.103819
PMCID: PMC12540038

Genes

KEAP1
NFE2L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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